Mice with Disseminated Candidiasis Die of Progressive Sepsis
نویسندگان
چکیده
منابع مشابه
Mice with disseminated candidiasis die of progressive sepsis.
BACKGROUND Candida species are among the most common etiologies of nosocomial bloodstream infections, causing a mortality of >40%. The murine model of hematogenously disseminated candidiasis is the standard for investigating both the activity of antifungal agents and the pathogenesis of this disease. However, despite decades of use, little is known about the physiological characteristics of the...
متن کاملIn vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
Objective(s): Systemic candidiasis is an infection of Candida albicans (C. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. We investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with Concanavalin A (Con A) and Pokeweed mitogen (PWM) in mice with dissem...
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Candida albicans vulvovaginitis during pregnancy has high prevalence and appears in up to 20-30% of pregnant women.1,2 However, the incidence of Candida Albicans ascending infection causing chorioamnionitis is less than 1%.3-5 But, when chorioamnionitis does happen, the consequences may be missed abortion, premature labor, intrauterine fetal death or Candida sepsis.4,5,7-10 The diagnosis of cho...
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We present a case of disseminated intracranial infection by Candida albicans in a 5-year-old girl who had fever and a change of consciousness after surgery for complex congenital heart malformation. MR imaging revealed multiple small ring-enhancing hemorrhagic abscesses. One year after antifungal treatment, the abscesses and ventriculomegaly were almost completely resolved. The patient was disc...
متن کاملin vitro lymphoproliferative response and cytokine production in mice with experimental disseminated candidiasis
objective(s): systemic candidiasis is an infection of candida albicans (c. albicans) causing disseminated disease and sepsis, invariably when host defenses are compromised. we investigated the histopathological changes as well as the lymphoproliferative responses and cytokine production of splenic cells after stimulation with concanavalin a (con a) and pokeweed mitogen (pwm) in mice with dissem...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2005
ISSN: 0022-1899,1537-6613
DOI: 10.1086/430952